effect_of_lifestyle_medication_and_ethnicity_on_cardiometabolic_risk_in_the_year_following_the_first_episode_of_psychosis_prospective_cohort_study.pdf (372.72 kB)
Effect of lifestyle, medication and ethnicity on cardiometabolic risk in the year following the first episode of psychosis: prospective cohort study
Version 2 2023-06-12, 09:12
Version 1 2023-06-09, 19:15
journal contribution
posted on 2023-06-12, 09:12 authored by Fiona Gaughran, Daniel Stahl, Dominic Stringer, David Hopkins, Zerrin Atakan, Kathryn GreenwoodKathryn Greenwood, Anita Patel, Shubulade Smith, Poonam Gardner-Sood, John Lally, Margaret Heslin, Brendon Stubbs, Stefania Bonaccorso, Anna Kolliakou, Oliver Howes, David Taylor, Marta Di Forti, Anthony S David, Robin M Murray, Khalida Ismail, the IMPACT teamBackground The first episode of psychosis (FEP) is a critical period in the emergence of cardiometabolic risk. Aims We set out to explore the influence of individual and lifestyle factors on cardometabolic outcomes in early psychosis. Method A prospective cohort study of 293 UK adults presenting with FEP investigating the influence of socio-demographics, lifestyle (physical activity, sedentary behaviour, nutrition, smoking, alcohol, substance use), and medication on cardiometabolic outcomes over the following 12 months. Results Rates of obesity and glucose dysregulation rose from 17.8% and 12% respectively at baseline to 23.7% and 23.7% at one year. Little change was seen over time in the 76.8% tobacco smoking rate or the quarter who were sedentary for over 10 hours daily. We found no association between lifestyle at baseline or type of anti-psychotic medication prescribed with either baseline or one-year cardiometabolic outcomes. Median Hba1c rose by 3.3 mmol/mol in participants from Black and minority ethnic (BME) groups, with little change observed in their white counterparts. At 12 months, one third of those with BME heritage exceeded the threshold for pre-diabetes (HbA1c >39mmol/mol). Conclusion Unhealthy lifestyle choices are prevalent in early psychosis and cardiometabolic risk worsens over the next year, creating an important window for prevention. We found no evidence however that preventative strategies should be preferentially directed based on lifestyle habits. Further work is needed to determine whether clinical strategies should allow for differential patterns of emergence of cardiometabolic risk in people of different ethnicities.
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Publication status
- Published
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- Published version
Journal
The British Journal of PsychiatryISSN
0007-1250Publisher
Cambridge University PressExternal DOI
Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-10-03First Open Access (FOA) Date
2019-10-03First Compliant Deposit (FCD) Date
2019-10-03Usage metrics
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