Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer

Soleimani, Atena, Rahmani, Farzad, Ferns, Gordon A, Ryzhikov, Mikhail, Avan, Amir and Hassanian, Seyed Mahdi (2019) Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene, 726 (a14413). ISSN 0378-1119

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Abstract

The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis, angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB pathway is a feature of colorectal cancer (CRC). While new combinatorial treatments have improved overall patient outcome; quality of life, cost of care, and patient survival rate have seen little improvement. Suppression of the NF-κB signaling pathway using biological or specific pharmacological inhibitors is a potential therapeutic approach in the treatment of colon cancer. This review summarizes the regulatory role of NF-κB signaling pathway in the pathogenesis of CRC for a better understanding and hence a better management of the disease.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > R Medicine (General)
Depositing User: Cherie Elody
Date Deposited: 01 Oct 2019 16:08
Last Modified: 20 Jan 2020 14:00
URI: http://sro.sussex.ac.uk/id/eprint/86512

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