Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

de Lange, Siemon C, Scholtens, Lianne H, van den Berg, Leonard H, Boks, Marco P, Bozzali, Marco, Cahn, Wiepke, Dannlowski, Udo, Durston, Sarah, Geuze, Elbert, van Haren, Neeltje E M, Hillegers, Manon H J, Koch, Kathrin, Jurado, María Ángeles, Mancini, Matteo, Marqués-Iturria, Idoia, Meinert, Susanne, Ophoff, Roel A, Reess, Tim J, Repple, Jonathan, Kahn, René S and van den Heuvel, Martijn P (2019) Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders. Nature Human Behaviour, 3 (9). pp. 988-998. ISSN 2397-3374

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Abstract

Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain's connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a 'cross-disorder disconnectivity involvement map' describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 01 Oct 2019 08:53
Last Modified: 31 Jan 2020 13:39
URI: http://sro.sussex.ac.uk/id/eprint/86218

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