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Multi-input synapses, but not LTP-strengthened synapses, correlate with hippocampal memory storage in aged mice
Version 2 2023-06-07, 08:29
Version 1 2023-06-07, 06:44
journal contribution
posted on 2023-06-07, 08:29 authored by Wajeeha AzizWajeeha Aziz, Igor Kraev, Keiko Mizuno, Alaistair Kirby, Ton Fang, Huzefa Rupawala, Kamillia KasbiKamillia Kasbi, Stephanie Rothe, Felix Josza, Kobi Rosenblum, Michael G Stewart, Karl Peter GieseLong-lasting changes at synapses enable memory storage in the brain. Although aging is associated with impaired memory formation, it is not known whether the synaptic underpinnings of memory storage differ with age. Using a training schedule that results in the same behavioral memory formation in young and aged mice, we examined synapse ultrastructure and molecular signaling in hippocampus after contextual fear conditioning. Only in young, but not old mice contextual fear memory formation was associated with synaptic changes that characterize well-known long-term potentiation,a strengthening of existing synapses with one input. Instead old age memory was correlated with generation of multi-innervated dendritic spines (MIS), which are predominantly two-input synapses formed by the attraction of an additional excitatory, presynaptic terminal onto an existing synapse. Accordingly, a blocker used to inhibit MIS generation impaired contextual fear memory only in old mice. Our results reveal how the synaptic basis of hippocampal memory storage changes with age and they suggest that these distinct memory-storing mechanisms may explain impaired updating in old age.
History
Publication status
- Published
File Version
- Published version
Journal
Current BiologyISSN
0960-9822Publisher
ElsevierExternal DOI
Issue
21Volume
29Page range
3600-3610Department affiliated with
- Division of Medical Education Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2019-09-20First Open Access (FOA) Date
2019-11-25First Compliant Deposit (FCD) Date
2019-09-20Usage metrics
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