Matrix-assisted DOSY

Day, Iain J (2019) Matrix-assisted DOSY. Progress in Nuclear Magnetic Resonance Spectroscopy. ISSN 0079-6565

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The analysis of mixtures by NMR spectroscopy is challenging. Diffusion-ordered NMR spectroscopy enables a pseudo-separation of species based on differences in their translational diffusion coefficients. Under the right circumstances, this is a powerful technique; however, when molecules diffuse at similar rates separation in the diffusion dimension can be poor. In addition, spectral overlap also limits resolution and can make interpretation challenging. Matrix-assisted diffusion NMR seeks to improve resolution in the diffusion dimension by utilising the differential interaction of components in the mixture with an additive to the solvent. Tuning these matrix-analyte interactions allows the diffusion resolution to be optimised. This review presents the background to matrix-assisted diffusion experiments, surveys the wide range of matrices employed, including chromatographic stationary phases, surfactants and polymers, and demonstrates the current state of the art.

Item Type: Article
Keywords: Diffusion NMR; Chromatography; Micelle; Surfactant; Polymer
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0071 Analytical chemistry
Depositing User: Iain Day
Date Deposited: 10 Sep 2019 16:14
Last Modified: 07 Mar 2021 02:00

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