Day, Iain J (2019) Matrix-assisted DOSY. Progress in Nuclear Magnetic Resonance Spectroscopy. ISSN 0079-6565
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Abstract
The analysis of mixtures by NMR spectroscopy is challenging. Diffusion-ordered NMR spectroscopy enables a pseudo-separation of species based on differences in their translational diffusion coefficients. Under the right circumstances, this is a powerful technique; however, when molecules diffuse at similar rates separation in the diffusion dimension can be poor. In addition, spectral overlap also limits resolution and can make interpretation challenging. Matrix-assisted diffusion NMR seeks to improve resolution in the diffusion dimension by utilising the differential interaction of components in the mixture with an additive to the solvent. Tuning these matrix-analyte interactions allows the diffusion resolution to be optimised. This review presents the background to matrix-assisted diffusion experiments, surveys the wide range of matrices employed, including chromatographic stationary phases, surfactants and polymers, and demonstrates the current state of the art.
Item Type: | Article |
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Keywords: | Diffusion NMR; Chromatography; Micelle; Surfactant; Polymer |
Schools and Departments: | School of Life Sciences > Chemistry |
Subjects: | Q Science > QD Chemistry > QD0071 Analytical chemistry |
Depositing User: | Iain Day |
Date Deposited: | 10 Sep 2019 16:14 |
Last Modified: | 07 Mar 2021 02:00 |
URI: | http://sro.sussex.ac.uk/id/eprint/86047 |
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