Evaluation of the causal effects between dopamine infusion changeover and fluctuations in mean arterial pressure in neonates

Kirupakaran, Katherine, de Sousa, Paula, Le Roux, Celine, Redwood, Lauren, Rabe, Heike and Anil Patel, Bhavik (2019) Evaluation of the causal effects between dopamine infusion changeover and fluctuations in mean arterial pressure in neonates. British Medical Journal (BMJ). ISSN 0959-8138

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OBJECTIVE To evaluate whether changing dopamine infusions every 12 hours and preparing these infusions 30 minutes before administration reduces blood pressure fluctuations in pre-term and term neonates.
DESIGN This was a retrospective study using data from live patients on the neonatal unit and prospective study exploring stability of infusions in a laboratory based neonatal ward simulation.
SETTING Single centre study in a tertiary neonatal surgical unit in a university teaching hospital.
PATIENTS Neonates who received more than one subsequent dopamine infusion and had invasive arterial blood pressure monitoring, during their admission in the neonatal unit, were included.
INTERVENTIONS As part of the Quality Improvement project the SOP was changed, and dopamine infusions were prepared by nursing staff and left to rest for 30 minutes before administering to the neonate. Additionally, infusions were replaced every 12 hours.
MAIN OUTCOME MEASURES The percentage change in mean arterial pressure (MAP) and the percentage loss in the drug concentration during infusion during changeover.
RESULTS Our findings indicate that up to 15 % of the initial dopamine concentration is lost after 24 hours. This results in a sharp variation in the dopamine concentration during infusion changeover that correlates with observed rapid fluctuations in MAP. In changing the SOP, no signficant difference in the concentration of dopamine and MAP were observed over 12-hours.
CONCLUSIONS Delaying administration of dopamine infusions by 30 minutes after preparation combined with changing infusions 12 hourly has reduced MAP fluctuations. Therefore, the risks associated with MAP fluctuations, including intraventricular haemorrhages, are reduced.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RJ Pediatrics > RJ0251 Newborn infants Including physiology, care, treatment, diseases
Depositing User: Katie Isaac
Date Deposited: 11 Sep 2019 15:35
Last Modified: 11 Sep 2019 15:46
URI: http://sro.sussex.ac.uk/id/eprint/86004

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