2019 - Paper, Communications Biolgy.pdf (2.37 MB)
Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping
journal contribution
posted on 2023-06-09, 18:52 authored by Rosemary Lane, Thomas Simon, Marian Vintu, Benjamin Solkin, Barbara Koch, Nicolas Stewart, Graeme Benstead-Hume, Frances PearlFrances Pearl, Giles Critchley, Justin Stebbing, Georgios GiamasGeorgios GiamasGlioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids, recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up. The aim of the current study was to describe the protein content of sEVs produced by different GBM cell lines and patient-derived stem cells. Our results reveal that the content of the sEVs mirrors the phenotypic signature of the respective GBM cells, leading to the description of potential informative sEV-associated biomarkers for GBM subtyping, such as CD44. Overall, these data could assist future GBM in vitro studies and provide insights for the development of new diagnostic and therapeutic methods as well as personalized treatment strategies.
Funding
Deciphering the paracrine role of stromal cells in cancer development; G2467; ACTION AGAINST CANCER; 012018-02
History
Publication status
- Published
File Version
- Published version
Journal
Communications BiologyISSN
2399-3642Publisher
Nature ResearchExternal DOI
Volume
2Article number
a315Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-09-03First Open Access (FOA) Date
2019-09-03First Compliant Deposit (FCD) Date
2019-09-01Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC