Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

Lane, Rosemary, Simon, Thomas, Vintu, Marian, Solkin, Benjamin, Koch, Barbara, Stewart, Nicolas, Benstead-Hume, Graeme, Pearl, Frances M G, Critchley, Giles, Stebbing, Justin and Giamas, Georgios (2019) Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping. Communications Biology, 2. a315. ISSN 2399-3642

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Abstract

Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids, recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up. The aim of the current study was to describe the protein content of sEVs produced by different GBM cell lines and patient-derived stem cells. Our results reveal that the content of the sEVs mirrors the phenotypic signature of the respective GBM cells, leading to the description of potential informative sEV-associated biomarkers for GBM subtyping, such as CD44. Overall, these data could assist future GBM in vitro studies and provide insights for the development of new diagnostic and therapeutic methods as well as personalized treatment strategies.

Item Type: Article
Keywords: extracellular vesicles, glioblastoma, biomarkers, subtyping
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science
Q Science > Q Science (General) > Q0179.9 Research
Depositing User: Georgios Giamas
Date Deposited: 03 Sep 2019 18:17
Last Modified: 04 Sep 2019 07:00
URI: http://sro.sussex.ac.uk/id/eprint/85877

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