Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

Fontana, Gabriele A and Rass, Ulrich (2019) Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane. Molecular & Cellular Oncology. ISSN 2372-3556

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Abstract

DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.

Item Type: Article
Keywords: DNA repair; DNA double-strand break repair; non-homologous end-joining; chromosome stability; protein palmitoylation; Rif1; Pfa4
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Research Centres and Groups: Genome Damage and Stability Centre
Subjects: Q Science > Q Science (General) > Q0179.9 Research
Q Science > Q Science (General)
Depositing User: Ulrich Rass
Date Deposited: 29 Aug 2019 11:57
Last Modified: 29 Aug 2019 12:00
URI: http://sro.sussex.ac.uk/id/eprint/85727

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