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Compartmentalized DNA repair Rif1 S acylation links DNA double strand break repair to the nuclear membrane.pdf (2.33 MB)

Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

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journal contribution
posted on 2023-06-09, 18:36 authored by Gabriele A Fontana, Ulrich RassUlrich Rass
DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.

History

Publication status

  • Published

File Version

  • Published version

Journal

Molecular & Cellular Oncology

ISSN

2372-3556

Publisher

Taylor & Francis

External DOI

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Research groups affiliated with

  • Genome Damage and Stability Centre Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-08-29

First Open Access (FOA) Date

2019-08-29

First Compliant Deposit (FCD) Date

2019-08-29

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    University of Sussex (Publications)

    Categories

    No categories selected

    Keywords

    DNA repair; DNA double-strand break repair; non-homologous end-joining; chromosome stability; protein palmitoylation; Rif1; Pfa4

    Licence

    CC BY-NC 4.0

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