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Responses to executive demand in young adulthood differ by APOE genotype
journal contribution
posted on 2023-06-09, 18:26 authored by Rebecca AtkinsonRebecca Atkinson, Darya GaysinaDarya Gaysina, Jennifer RustedDespite evidence of a relationship between Apolipoprotein E (APOE) e4+ and later-life cognitive decline, the lifespan effects of carrying an e4+ allele on cognitive ageing are not well understood. Evidence of e4+ advantages in early-life are inconsistent, but not inconsiderable. We explored the proposal that APOE e4+ cognitive advantages arise only in response to complex and sensitive tasks targeting specific executive functions. We systematically manipulated executive demand within verbal fluency, decision-making, prospective memory, and sustained attention tasks. Participants aged 18–25 years (21 e4+, 63 e33) also completed a measure of subjective effort. Under low executive demand, e4+ made fewer verbal fluency word repeats compared to e33 carriers. Under high executive demand, e4+ showed lower costs associated with performing concurrent tasks, greater switching errors, and more verbal fluency root repetition errors. Overall, e4+ appeared to be showing working memory updating advantages under conditions of low executive demand, more effective resource allocation under elevated levels of executive demand, and errors indicating different strategy use compared to e33 carriers, including speed-accuracy trade-offs.
History
Publication status
- Published
File Version
- Accepted version
Journal
Behavioural Brain ResearchISSN
0166-4328Publisher
ElsevierExternal DOI
Volume
360Page range
158-168Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-07-18First Open Access (FOA) Date
2019-11-22First Compliant Deposit (FCD) Date
2019-07-17Usage metrics
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