Badiani2019_Article_OppositeEnvironmentalGatingOfT.pdf (2.95 MB)
Opposite environmental gating of the experienced utility (‘liking’) and decision utility (‘wanting’) of heroin versus cocaine in animals and humans: implications for computational neuroscience
Version 2 2023-06-12, 09:10
Version 1 2023-06-09, 18:23
journal contribution
posted on 2023-06-12, 09:10 authored by Aldo Badiani, Daniele Caprioli, Silvana De PirroSilvana De PirroBackground In this paper, we reviewed translational studies concerned with environmental influences on the rewarding effects of heroin versus cocaine in rats and humans with substance use disorder. These studies show that both experienced utility (‘liking’) and decision utility (‘wanting’) of heroin and cocaine shift in opposite directions as a function of the setting in which these drugs were used. Briefly, rats and humans prefer using heroin at home but cocaine outside the home. These findings appear to challenge prevailing theories of drug reward, which focus on the notion of shared substrate of action for drug of abuse, and in particular on their shared ability to facilitate dopaminergic transmission. Aims Thus, in the second part of the paper, we verified whether our findings could be accounted for by available computational models of reward. To account for our findings, a model must include a component that could mediate the substance-specific influence of setting on drug reward Results It appears of the extant models that none is fully compatible with the results of our studies. Conclusions We hope that this paper will serve as stimulus to design computational models more attuned to the complex mechanisms responsible for the rewarding effects of drugs in real-world contexts.
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Publication status
- Published
File Version
- Published version
Journal
PsychopharmacologyISSN
0033-3158Publisher
Springer VerlagExternal DOI
Department affiliated with
- Psychology Publications
Research groups affiliated with
- Sussex Addiction Research and Intervention Centre (SARIC) Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-07-11First Open Access (FOA) Date
2019-07-11First Compliant Deposit (FCD) Date
2019-07-11Usage metrics
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