__smbhome.uscs.susx.ac.uk_sc328_Desktop_Papers for SRO_SINGER_European_Journal_of_Neuroscience_JUL_2014_author_copy.pdf (1.85 MB)
Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery
journal contribution
posted on 2023-06-09, 18:16 authored by Caitlin M Vander Weele, Kirsten A Porter-Stransky, Omar S Mabrouk, Vedran Lovic, Bryan SingerBryan Singer, Robert T Kennedy, Brandon J AragonaWhile most drugs of abuse increase dopamine neurotransmission, rapid neurochemical measurements show that different drugs evoke distinct dopamine release patterns within the nucleus accumbens. Rapid changes in dopamine concentration following psychostimulant administration have been well studied; however, such changes have never been examined following opioid delivery. Here, we provide novel measures of rapid dopamine release following intravenous infusion of two opioids, morphine and oxycodone, in drug-naïve rats using fast-scan cyclic voltammetry and rapid (1 min) microdialysis coupled with high-performance liquid chromatography - tandem mass spectrometry (HPLC-MS). In addition to measuring rapid dopamine transmission, microdialysis HPLC-MS measures changes in GABA, glutamate, monoamines, monoamine metabolites and several other neurotransmitters. Although both opioids increased dopamine release in the nucleus accumbens, their patterns of drug-evoked dopamine transmission differed dramatically. Oxycodone evoked a robust and stable increase in dopamine concentration and a robust increase in the frequency and amplitude of phasic dopamine release events. Conversely, morphine evoked a brief (~ 1 min) increase in dopamine that was coincident with a surge in GABA concentration and then both transmitters returned to baseline levels. Thus, by providing rapid measures of neurotransmission, this study reveals previously unknown differences in opioid-induced neurotransmitter signaling. Investigating these differences may be essential for understanding how these two drugs of abuse could differentially usurp motivational circuitry and powerfully influence behavior.
History
Publication status
- Published
File Version
- Accepted version
Journal
European Journal of NeuroscienceISSN
0953-816XPublisher
WileyExternal DOI
Issue
7Volume
40Page range
3041-3054Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-07-01First Open Access (FOA) Date
2019-07-01First Compliant Deposit (FCD) Date
2019-06-28Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC