Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine

Singer, Bryan F, Bryan, Myranda A, Popov, Pavlo, Robinson, Terry E and Aragona, Brandon J (2017) Rapid induction of dopamine sensitization in the nucleus accumbens shell induced by a single injection of cocaine. Behavioural Brain Research, 324. pp. 66-70. ISSN 01664328

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Abstract

Repeated intermittent exposure to cocaine results in the neurochemical sensitization of dopamine (DA) transmission within the nucleus accumbens (NAc). Indeed, the excitability of DA neurons in the ventral tegmental area (VTA) is enhanced within hours of initial psychostimulant exposure. However, it is not known if this is accompanied by a comparably rapid change in the ability of cocaine to increase extracellular DA concentrations in the ventral striatum. To address this question we used fast-scan cyclic voltammetry (FSCV) in awake-behaving rats to measure DA responses in the NAc shell following an initial intravenous cocaine injection, and then again 2-hours later. Both injections quickly elevated DA levels in the NAc shell, but the second cocaine infusion produced a greater effect than the first, indicating sensitization. This suggests that a single injection of cocaine induces sensitization-related plasticity very rapidly within the mesolimbic DA system.

Item Type: Article
Keywords: Cocaine; sensitization; dopamine; voltammetry; nucleus accumbens; psychostimulant
Schools and Departments: School of Psychology > Psychology
Depositing User: Sanjeedah Choudhury
Date Deposited: 24 Jun 2019 15:33
Last Modified: 01 Jul 2019 12:00
URI: http://sro.sussex.ac.uk/id/eprint/84555

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