Manuscript_Muller_Nedebock_mtDNA_in_PD_resubmission.pdf (457.93 kB)
The unresolved role of mitochondrial DNA in Parkinson’s disease: an overview of published studies, their limitations, and future prospects
journal contribution
posted on 2023-06-09, 18:08 authored by Amica C Müller-Nedebock, Rebecca R Brennan, Marianne Venter, Ilse Pienaar, Francois H van der Westhuizen, Joanna L Elson, Owen A Ross, Soraya BardienParkinson’s disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are highly dependent on mitochondrial adenosine triphosphate (ATP) and degenerate in PD. Mitochondria contain their own genomes (mtDNA). The role of mtDNA has been investigated in PD on the premise that it encodes vital components of the ATP-generating oxidative phosphorylation (OXPHOS) complexes and accumulates somatic variation with age. However, the association between mtDNA variation and PD remains controversial. Herein, we provide an overview of previously published studies on the role of inherited as well as somatic (acquired) mtDNA changes in PD including point mutations, deletions and depletion. We outline limitations of previous investigations and the difficulties associated with studying mtDNA, which have left its role unresolved in the context of PD. Lastly, we highlight the potential for further research in this field and provide suggestions for future studies. Overall, the mitochondrial genome is indispensable for proper cellular function and its contribution to PD requires further, more extensive investigation.
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Publication status
- Published
File Version
- Accepted version
Journal
Neurochemistry InternationalISSN
0197-0186Publisher
ElsevierExternal DOI
Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-06-24First Open Access (FOA) Date
2020-06-21First Compliant Deposit (FCD) Date
2019-06-21Usage metrics
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