Prognostic value.pdf (313.38 kB)
Prognostic value of high mobility group protein A2 (HMGA2) over-expression in cancer progression
journal contribution
posted on 2023-06-09, 18:05 authored by Maryam Moradi Binabaj, Atena Soleimani, Farzad Rahmani, Amir Avan, Majid Khazaei, Hamid Fiuji, Saman Soleimanpour, Mikhail Ryzhikov, Gordon FernsGordon Ferns, Afsane Bahrami, Seyed Mahdi HassanianThe high mobility group A2 (HMGA2; also called HMGI-C) gene is an architectural transcription factor that belonging to the high mobility group AT-hook (HMGA) gene family. HMGA2 is aberrantly regulated in several human tumors. Over-expression of HMGA2 is correlated with a higher risk of metastasis and an unfavorable prognosis in patients with cancer. We performed a meta-analysis to determine the clinic-pathological and prognostic value of HMGA2 overexpression in different human tumors. A comprehensive literature search was performed using PubMed, Embase, Cochrane Library, Scopus, MEDLINE, Google Scholar and ISI Web of Science. Hazard ratios (HRs)/odds ratios (ORs) and their 95% confidence intervals (CIs) were used to assess the strength of the association between HMGA2 expression and overall survival (OS)/progression free survival (PFS)/disease free survival (DFS). A total of 5319 patients with 19 different types of cancer from 35 articles were evaluated. Pooled data analysis indicated that increased HMGA2 expression in cancer patients predicted a poor OS (HR?=?1.70; 95% CI?=?1.6–1.81; P?
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Publication status
- Published
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- Accepted version
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GeneISSN
0378-1119Publisher
ElsevierExternal DOI
Volume
706Page range
131-139Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-06-17First Open Access (FOA) Date
2020-05-02First Compliant Deposit (FCD) Date
2019-06-14Usage metrics
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