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Signaling via the NF?B system

journal contribution
posted on 2023-06-20, 14:15 authored by Simon MitchellSimon Mitchell, Jesse Vargas, Alexander Hoffmann
The nuclear factor kappa B (NF?B) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NF?B signaling system (defined by the interactions between NF?B dimers, I?B regulators, and IKK complexes) is responsive to a number of stimuli, and upon ligand–receptor engagement, distinct cellular outcomes, appropriate to the specific signal received, are set into motion. After almost three decades of study, many signaling mechanisms are well understood, rendering them amenable to mathematical modeling, which can reveal deeper insights about the regulatory design principles. While other reviews have focused on upstream, receptor proximal signaling (Hayden MS, Ghosh S. Signaling to NF-?B. Genes Dev 2004, 18:2195–2224; Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-?B: variations on a common theme. Cell Mol Life Sci 2008, 65:2964–2978), and advances through computational modeling (Basak S, Behar M, Hoffmann A. Lessons from mathematically modeling the NF-?B pathway. Immunol Rev 2012, 246:221–238; Williams R, Timmis J, Qwarnstrom E. Computational models of the NF-KB signalling pathway. Computation 2014, 2:131), in this review we aim to summarize the current understanding of the NF?B signaling system itself, the molecular mechanisms, and systems properties that are key to its diverse biological functions, and we discuss remaining questions in the field.

History

Publication status

  • Published

Journal

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

ISSN

1939-5094

Publisher

Wiley

Issue

3

Volume

8

Page range

227-241

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2019-06-17

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    University of Sussex (Publications)

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