noiseReviewResubmit2ahsm.pdf (446.81 kB)
Identifying noise sources governing cell-to-cell variability
journal contribution
posted on 2023-06-09, 18:04 authored by Simon MitchellSimon Mitchell, Alexander HoffmannPhenotypic differences often occur even in clonal cell popu- lations. Many potential sources of such variation have been identified, from biophysical rate variance intrinsic to all chem- ical processes to asymmetric division of molecular compo- nents extrinsic to any particular signaling pathway. Identifying the sources of phenotypic variation and quantifying their con- tributions to cell fate variation is not possible without accurate single cell data. By combining such data with mathematical models of potential noise sources it is possible to characterize the impact of varying levels of each noise source and identify which sources of variation best explain the experimental ob- servations. The mathematical framework of information theory provides metrics of the impact of noise on the reliability of a cell to sense its environment. While the presence of noise in a single cellular system reduces the reliability of signal trans- duction its impact on a population of varied single cells remains unclear.
History
Publication status
- Published
File Version
- Accepted version
Journal
Current Opinion in Systems BiologyISSN
2452-3100Publisher
ElsevierExternal DOI
Volume
8Page range
39-45Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-06-14First Open Access (FOA) Date
2019-06-19First Compliant Deposit (FCD) Date
2019-06-13Usage metrics
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