Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent

Crossley, Michael, Lorenzetti, Frederick D, Naskar, Souvik, O'Shea, Michael, Kemenes, György, Benjamin, Paul R and Kemenes, Ildikó (2019) Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent. Communications Biology, 2 (242). pp. 1-11. ISSN 2399-3642

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Abstract

Interference-based forgetting occurs when new information acquired either before or after a learning event attenuates memory expression (proactive and retroactive interference, respectively). Multiple learning events often occur in rapid succession, leading to competition
between consolidating memories. However, it is unknown what factors determine which memory is remembered or forgotten. Here, we challenge the snail, Lymnaea, to acquire two consecutive similar or different memories and identify learning-induced changes in neurons of its well-characterized motor circuits. We show that when new learning takes place during a stable period of the original memory, proactive interference only occurs if the two consolidating memories engage the same circuit mechanisms. If different circuits are used, both memories survive. However, any new learning during a labile period of consolidation promotes retroactive interference and the acquisition of the new memory. Therefore, the effect of interference depends both on the timing of new learning and the underlying neuronal mechanisms.

Item Type: Article
Keywords: memory consolidation, proactive interference, retroactive interference, memory lapse, memory replacement, neuronal mechanisms, Lymnaea
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Subjects: Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology
Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system
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Depositing User: Ildiko Kemenes
Date Deposited: 14 Jun 2019 10:48
Last Modified: 18 Jul 2019 12:30
URI: http://sro.sussex.ac.uk/id/eprint/84305

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