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Proactive and retroactive interference with associative memory consolidation in the snail Lymnaea is time and circuit dependent

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posted on 2023-06-07, 06:35 authored by Michael CrossleyMichael Crossley, Frederick D Lorenzetti, Souvik Naskar, Michael O'Shea, George KemenesGeorge Kemenes, Paul R Benjamin, Ildiko KemenesIldiko Kemenes
Interference-based forgetting occurs when new information acquired either before or after a learning event attenuates memory expression (proactive and retroactive interference, respectively). Multiple learning events often occur in rapid succession, leading to competition between consolidating memories. However, it is unknown what factors determine which memory is remembered or forgotten. Here, we challenge the snail, Lymnaea, to acquire two consecutive similar or different memories and identify learning-induced changes in neurons of its well-characterized motor circuits. We show that when new learning takes place during a stable period of the original memory, proactive interference only occurs if the two consolidating memories engage the same circuit mechanisms. If different circuits are used, both memories survive. However, any new learning during a labile period of consolidation promotes retroactive interference and the acquisition of the new memory. Therefore, the effect of interference depends both on the timing of new learning and the underlying neuronal mechanisms.

Funding

Lapses in memory: opportunities for adaptive behaviour; G1199; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/K018515/1

Updating of memories during memory consolidation; G2208; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/P00766X/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Communications Biology

ISSN

2399-3642

Publisher

Springer Nature

Issue

242

Volume

2

Page range

1-11

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-06-14

First Open Access (FOA) Date

2019-06-14

First Compliant Deposit (FCD) Date

2019-06-13

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