J Nucl Med-2017-Datta-jnumed.116.187161.pdf (1.4 MB)
11C-PBR28 and 18F-PBR111 detect white matter inflammatory heterogeneity in multiple sclerosis
journal contribution
posted on 2023-06-07, 06:34 authored by Gourab Datta, Alessandro ColasantiAlessandro Colasanti, Nicola Kalk, David Owen, Gregory Scott, Eugenii A Rabiner, Roger N Gunn, Anne Lingford-Hughes, Omar Malik, Olga Ciccarelli, Richard Nicholas, Lei Nei, Marco Battaglini, Nicola D Stefano, Paul M MatthewsThe objective of this study was to assess microglial activation in lesions and in normal-appearing white matter (NAWM) of multiple sclerosis (MS) patients using PET. Methods: Thirty-four MS patients (7 with secondary progressive MS [SPMS], 27 with relapsing remitting MS [RRMS]) and 30 healthy volunteers, genetically stratified for translocator protein (TSPO) binding status, underwent PET scanning with TSPO radioligands (11C-PBR28 or 18F-PBR111). Regional TSPO availability was measured as a distribution volume ratio (DVR) relative to the caudate (a pseudoreference region). White matter lesions (WMLs) were classified as "active" (DVR highest in the lesion), "peripherally active" (perilesional DVR highest), "inactive" (DVR highest in surrounding NAWM), or "undifferentiated" (similar DVR across lesion, perilesional and NAWM volumes). Results: The mean DVR in NAWM of patients was greater than that of the healthy volunteer white matter for both radioligands. Uptake for individual WML in patients was heterogeneous, but the median WML DVR and NAWM DVR for individual patients were strongly correlated (? = 0.94, P = 4 × 10-11). A higher proportion of lesions were inactive in patients with SPMS (35%) than RRMS (23%), but active lesions were found in all patients, including those on highly efficacious treatments. Conclusion: TSPO radioligand uptake was increased in the brains of MS patients relative to healthy controls with 2 TSPO radiotracers. WML showed heterogeneous patterns of uptake. Active lesions were found in patients with both RRMS and SPMS. Their independent prognostic significance needs further investigation.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Nuclear MedicineISSN
0161-5505Publisher
Society of Nuclear MedicineExternal DOI
Issue
9Volume
58Page range
1477-1482Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-05-31First Open Access (FOA) Date
2019-06-04First Compliant Deposit (FCD) Date
2019-05-31Usage metrics
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