Association between non-alcoholic fatty liver disease and colorectal cancer

Parizadeh, Seyed Mostafa, Parizade, Seyed Alireza, Alizade-Noghani, Mohadese, Jafarzadeh-Esfehani, Reza, Ghandehari, Maryam, Mottaghi-Moghaddam, Ali, Goldani, Fatemeh, Khazaei, Majid, Ghayour-Mobarhan, Majid, Ferns, Gordon A, Hassanian, Seyed Mahdi and Avan, Amir (2019) Association between non-alcoholic fatty liver disease and colorectal cancer. Expert Review of Gastroenterology and Hepatology. ISSN 1747-4124

[img] PDF (This is an Accepted Manuscript of an article published by Taylor & Francis Group in Expert Review of Gastroenterology & Hepatology on 16/05/2019, available online: https://www.tandfonline.com/doi/full/10.1080/17474124.2019.1617696) - Accepted Version
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Abstract

Introduction: Colorectal cancer (CRC) is a common malignancy and ranking fourth among the causes of cancer-related deaths globally. Its incidence has increased in recent decades, and now more than one million CRC patients are diagnosed and thousands die annually. The 5-year survival rate varies with the stage at diagnosis, being approximately 90% in the early stages of disease, and less than 10% in advanced disease. Nonalcoholic fatty liver disease (NAFLD), which is a major cause of chronic liver disease, and characterized by the accumulation of fat in hepatocytes, has also emerged as a risk factor for CRC, and to be related with the development of colorectal polyps.

Areas covered: The purpose of this current review is to summarize the main findings of studies that have investigated the role of NAFLD in development of CRC.

Expert commentary: Various molecular pathways, are altered during the development of NAFLD, which are also important in CRC tumorigenesis. There is growing body of evidence showing the potential role of activation of pro-inflammatory, disruption of antiinflammatory pathways, increasing the activity of pathways involved in cell proliferation/survival. Thus targeting these deregulated pathways via novel inhibitors can be a potential therapy for CRC prevention in cases with NAFLD.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > R Medicine (General)
Depositing User: Cherie Elody
Date Deposited: 14 Jun 2019 10:38
Last Modified: 16 May 2020 01:00
URI: http://sro.sussex.ac.uk/id/eprint/83861

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