Common polymorphisms ATU.pdf (409.49 kB)
Common polymorphisms in genes related to vitamin D metabolism affect the response of cognitive abilities to vitamin D supplementation
journal contribution
posted on 2023-06-09, 17:50 authored by Afsane Bahrami, Sayyed Saeid Khayyatzadeh, Najmeh Jaberi, Maryam Tayefi, Farzaneh Mohammadi, Gordon FernsGordon Ferns, Hamid Reza Sadeghnia, Majid Ghayour-MobarhanIt is possible that vitamin D acts as a neurosteroid and that vitamin D deficiency may have an adverse impact on brain function and cognitive function. There are a few reports that have demonstrated an association between polymorphisms of genes involved in vitamin D metabolism and neurodegenerative disease. We aimed to evaluate the relationship between common, functional vitamin D–associated gene variants and cognitive abilities and to investigate the effect size of this polymorphism on cognitive capabilities associated with high-dose vitamin D supplementation. A total of 319 healthy adolescents received a high dose of vitamin D (50,000 IU)/week for 9 weeks. A questionnaire was used to assess cognitive abilities at baseline and after treatment. The genotypes of the CYP2R1-rs10766197 and GC-rs4588 variants were determined using TaqMan genotyping techniques. At baseline, total cognitive ability scores were higher in the AA group who were homozygous for the uncommon allele, compared with the other (AG and GG) genotypes of the CYP2R1-rs10766197 polymorphism (104.9?±?27.8 vs. 79.1?±?38.8 vs. 73.1?±?25.6; p?
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Publication status
- Published
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- Accepted version
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Journal of Molecular NeuroscienceISSN
0895-8696Publisher
SpringerExternal DOI
Department affiliated with
- Division of Medical Education Publications
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- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-06-14First Open Access (FOA) Date
2020-07-16First Compliant Deposit (FCD) Date
2019-06-13Usage metrics
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