Does post-stroke white coate hypertension/effect (WCH/E) require intensive blood pressure management?

Rajkumar, Chakravarthi, Ali, Khalid and Okorie, Michael (2019) Does post-stroke white coate hypertension/effect (WCH/E) require intensive blood pressure management? 29th European meeting on hypertension and cardiovascular protection, Milan, Italy, 21st - 24th June 2019. Published in: Journal of Hypertension. 37 (1) Lippincott, Williams & Wilkins ISSN 0263-6352

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Abstract

Objective:
International guidelines advocate conservative management of post-stroke white coat hypertension. The aims of this study were; i) does WCH/E result in increased stroke risk? and ii) is WCH/E associated with surrogate markers of cardiovascular risk?

Design and method:
The Arterial Stiffness In Lacunar Stroke and TIA (ASIST) study recruited 96 patients, age >40-year-old, with a confirmed diagnosis of transient ischaemic attack (TIA) or lacunar stroke in the preceding 14 days. Patients were grouped by BP phenotypes. Thirty-four patients were excluded (n = 6 declined ABPM, n = 3 masked hypertension, n = 25 sustained hypertension). Thirty-two patients with normal BP (clinic BP < 140/90 mmHg and day-time ABPM < 135/85 mmHg), and 30 patients with WCH/E (clinic BP >/= 140/90 mmHg and day-time ABPM < 135/85 mmHg) were recruited. Other surrogate markers measured were; Central aortic BP (SphygoCor, AtCor Medical), QKD100–60 interval and nocturnal dipping status (Diasys Integra II, Novocor).

Results:
Compared to the normotensive cohort, patients with WCH/E were older, had a higher body mass index (BMI) and a larger proportion of patients were on anti-hypertensive medication. Both, central systolic (145 ± 13 vs 118 ± 8, p < 0.001) and diastolic BP (82 ± 8 vs 76 ± 7, p = 0.004) were higher in WCH/E. The WCH/E cohort also had more lacunar strokes (p = 0.039).

Conclusions:
In this population of post-stroke patients, WCH/E was associated with higher prevalence of lacunar stroke. These individuals also had higher central pressures despite more patients being on anti-hypertensive treatment, suggesting that post-stroke WCH/E should be managed more aggressively.

Item Type: Conference Proceedings
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Depositing User: Marie Shelton
Date Deposited: 14 May 2019 15:45
Last Modified: 22 Jul 2022 13:53
URI: http://sro.sussex.ac.uk/id/eprint/83701

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