Thalamocortical disconnection affects the somatic marker and social cognition: a case report

Serra, Laura, Bruschini, Michela, Ottaviani, Cristina, Di Domenico, Carlotta, Fadda, Lucia, Caltagirone, Carlo, Cercignani, Mara, Carlesimo, Giovanni Augusto and Bozzali, Marco (2019) Thalamocortical disconnection affects the somatic marker and social cognition: a case report. Neurocase. ISSN 1465-3656

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Abstract

Thalamo-cortical connectivity was characterised in a patient with bilateral infarct of the thalami, without evidence of cognitive deficits in everyday life. Patient underwent social and emotional tests, Iowa Gambling Task (IGT), with and without concomitant heart rate variability (HRV) recording and at 3T-MRI to assess thalamo-cortical connectivity. Patient showed impairment at the IGT, in somatic marker, in emotions and theory of mind. MRI documented a bilateral damage of the centromedian-parafascicular complex. Patient's thalamic lesions disconnected brain areas involved in decision-making and autonomic regulation, affecting the somatic marker and resulting in the neuropsychological deficit exhibited by L.C.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 10 Apr 2019 12:15
Last Modified: 01 Jul 2019 16:45
URI: http://sro.sussex.ac.uk/id/eprint/83118

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