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Ribbon synapses and visual processing in the retina

journal contribution
posted on 2023-06-09, 17:28 authored by Leon LagnadoLeon Lagnado, Frank Schmitz
The first synapses transmitting visual information contain an unusual organelle, the ribbon, which is involved in the transport and priming of vesicles to be released at the active zone. The ribbon is one of many design features that allow efficient refilling of the active zone, which in turn enables graded changes in membrane potential to be transmitted using a continuous mode of neurotransmitter release. The ribbon also plays a key role in supplying vesicles for rapid and transient bursts of release that signal fast changes, such as the onset of light. We increasingly understand how the physiological properties of ribbon synapses determine basic transformations of the visual signal and, in particular, how the process of refilling the active zone regulates the gain and adaptive properties of the retinal circuit. The molecular basis of ribbon function is, however, far from clear.

History

Publication status

  • Published

File Version

  • Published version

Journal

Annual Review of Vision Science

ISSN

2374-4650

Publisher

Annual Reviews

Volume

1

Page range

235-262

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2019-04-03

First Compliant Deposit (FCD) Date

2019-04-03

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