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Ribbon synapses and visual processing in the retina
journal contribution
posted on 2023-06-09, 17:28 authored by Leon LagnadoLeon Lagnado, Frank SchmitzThe first synapses transmitting visual information contain an unusual organelle, the ribbon, which is involved in the transport and priming of vesicles to be released at the active zone. The ribbon is one of many design features that allow efficient refilling of the active zone, which in turn enables graded changes in membrane potential to be transmitted using a continuous mode of neurotransmitter release. The ribbon also plays a key role in supplying vesicles for rapid and transient bursts of release that signal fast changes, such as the onset of light. We increasingly understand how the physiological properties of ribbon synapses determine basic transformations of the visual signal and, in particular, how the process of refilling the active zone regulates the gain and adaptive properties of the retinal circuit. The molecular basis of ribbon function is, however, far from clear.
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Publication status
- Published
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- Published version
Journal
Annual Review of Vision ScienceISSN
2374-4650Publisher
Annual ReviewsVolume
1Page range
235-262Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2019-04-03First Compliant Deposit (FCD) Date
2019-04-03Usage metrics
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