Small and large steps - advanced access.pdf (327 kB)
Does adaptive protein evolution proceed by large or small steps at the amino acid level?
journal contribution
posted on 2023-06-09, 17:16 authored by Juraj Bergman, Adam Eyre-WalkerAdam Eyre-WalkerA long-standing question in evolutionary biology is the relative contribution of large and small effect mutations to the adaptive process. We have investigated this question in proteins by estimating the rate of adaptive evolution between all pairs of amino acids separated by one mutational step using a McDonald-Kreitman type approach and genome-wide data from several Drosophila species. We find that the rate of adaptive evolution is highest amongst amino acids that are more similar. This is partly due to the fact that the proportion of mutations that are adaptive is higher amongst more similar amino acids. We also find that the rate of neutral evolution between amino acids is higher amongst more similar amino acids. Overall our results suggest that both the adaptive and non-adaptive evolution of proteins is dominated by substitutions between similar amino acids.
History
Publication status
- Published
File Version
- Accepted version
Journal
Molecular Biology and EvolutionISSN
0737-4038Publisher
Oxford University PressExternal DOI
Issue
5Volume
36Page range
990-998Department affiliated with
- Evolution, Behaviour and Environment Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-03-18First Open Access (FOA) Date
2020-02-14First Compliant Deposit (FCD) Date
2019-03-15Usage metrics
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