University of Sussex
Browse

File(s) not publicly available

An in vivo evaluation of the effects of local magnetic susceptibility-induced gradients on water diffusion measurements in human brain

journal contribution
posted on 2023-06-07, 13:50 authored by C. A. Clark, G. J. Barker, P. S. Tofts
The effect of possible susceptibility-induced gradients on measurements of water diffusion along the transverse and longitudinal axes of white matter fibers in the brain was investigated in vivo at 1.5 T. Measurements obtained with sequences sensitive and insensitive, respectively, to susceptibility-induced gradients indicated that these gradients do not contribute significantly to diffusion anisotropy in brain white matter. Furthermore, diffusion measurements were unaffected by the presence of known susceptibility-induced gradients at the interface between the petrous bone and brain parenchyma. These results agree with those obtained on in vitro samples and appear to support the hypothesis that interactions between the diffusing water molecules and the cellular environment constitute the principal mechanism for diffusion anisotropy in brain white matter at 1.5 T. This, in turn, simplifies the interpretation of diffusion time-dependent measurements in terms of membrane separation and permeability.

History

Publication status

  • Published

Journal

Journal of Magnetic Resonance

ISSN

1090-7807

Publisher

Elsevier

Issue

1

Volume

141

Page range

52-61

Department affiliated with

  • BSMS Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2007-02-28

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC