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An in vivo evaluation of the effects of local magnetic susceptibility-induced gradients on water diffusion measurements in human brain
journal contribution
posted on 2023-06-07, 13:50 authored by C. A. Clark, G. J. Barker, P. S. ToftsThe effect of possible susceptibility-induced gradients on measurements of water diffusion along the transverse and longitudinal axes of white matter fibers in the brain was investigated in vivo at 1.5 T. Measurements obtained with sequences sensitive and insensitive, respectively, to susceptibility-induced gradients indicated that these gradients do not contribute significantly to diffusion anisotropy in brain white matter. Furthermore, diffusion measurements were unaffected by the presence of known susceptibility-induced gradients at the interface between the petrous bone and brain parenchyma. These results agree with those obtained on in vitro samples and appear to support the hypothesis that interactions between the diffusing water molecules and the cellular environment constitute the principal mechanism for diffusion anisotropy in brain white matter at 1.5 T. This, in turn, simplifies the interpretation of diffusion time-dependent measurements in terms of membrane separation and permeability.
History
Publication status
- Published
Journal
Journal of Magnetic ResonanceISSN
1090-7807Publisher
ElsevierExternal DOI
Issue
1Volume
141Page range
52-61Department affiliated with
- BSMS Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2007-02-28Usage metrics
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