Original antigenic sin shapes the immunological repertoire ....pdf (776.07 kB)
Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive recipients
journal contribution
posted on 2023-06-09, 17:09 authored by Ilona Baraniak, Florian KernFlorian Kern, Pavlo Holenya, Paul Griffiths, Matthew ReevesA cytomegalovirus (CMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in CMV infected individuals (CMV+). Using sera from CMV+ gB/MF59 vaccine recipients prior to transplant we investigated the composition of the immune response. Vaccination boosted pre-existing humoral responses in our CMV+ cohort but did not promote de-novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination (‘original antigenic sin’). Thus vaccination of CMV+ may require strategies of epitope presentation distinct from those intended to prevent primary infection.
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Publication status
- Published
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- Accepted version
Journal
The Journal of Infectious DiseasesISSN
0022-1899Publisher
Oxford University PressExternal DOI
Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-03-07First Open Access (FOA) Date
2020-02-27First Compliant Deposit (FCD) Date
2019-03-07Usage metrics
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