Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive recipients

Baraniak, Ilona, Kern, Florian, Holenya, Pavlo, Griffiths, Paul and Reeves, Matthew (2019) Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive recipients. The Journal of Infectious Diseases. ISSN 0022-1899

[img] PDF (This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Infectious Diseases following peer review. The version of record is available online at: http://dx.doi.org/10.1093/infdis/jiz089) - Accepted Version
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Abstract

A cytomegalovirus (CMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in CMV infected individuals (CMV+). Using sera from CMV+ gB/MF59 vaccine recipients prior to transplant we investigated the composition of the immune response. Vaccination boosted pre-existing humoral responses in our CMV+ cohort but did not promote de-novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination (‘original antigenic sin’). Thus vaccination of CMV+ may require strategies of epitope presentation distinct from those intended to prevent primary infection.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User: Sandy Gray
Date Deposited: 07 Mar 2019 11:25
Last Modified: 01 Jul 2019 18:01
URI: http://sro.sussex.ac.uk/id/eprint/82365

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