Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo

Tofts, P. S., Lloyd, D., Clark, C. A., Barker, G. J., Parker, G. J., McConville, P., Baldock, C. and Pope, J. M. (2000) Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo. Magnetic Resonance in Medicine, 43 (3). pp. 368-374. ISSN 0740-3194

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A range of liquids suitable as quality control test objects for measuring the accuracy of clinical MRI diffusion sequences (both apparent diffusion coefficient and tensor) has been identified and characterized. The self-diffusion coefficients for 15 liquids (3 cyclic alkanes: cyclohexane to cyclooctane, 9 n-alkanes: n-octane to n-hexadecane, and 3 n-alcohols: ethanol to 1-propanol were measured at 15-30 degrees C using an NMR spectrometer. Values at 22 degrees C range from 0.36 to 2.2 10(-9) m(2)s(-1). Typical 95% confidence limits are +/-2%. Temperature coefficients are 1.7-3.2% degrees C. T1 and T2 values at 1.5 T and proton density are given. n-tridecane has a diffusion coefficient close to that of normal white matter. The longer n-alkanes may be useful T2 standards. Measurements from a spin-echo MRI sequence agreed to within 2%.

Item Type: Article
Keywords: Alcohols, Chemistry, Alkanes, Diffusion, Magnetic Resonance Imaging, Mathematics, Phantoms, Imaging, Temperature, Water
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 28 Feb 2007
Last Modified: 03 Sep 2019 11:30
URI: http://sro.sussex.ac.uk/id/eprint/821
Google Scholar:82 Citations
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