An overview of microRNAs as biomarkers of ALS

Joilin, Greig, Leigh, P Nigel, Newbury, Sarah F and Hafezparast, Majid (2019) An overview of microRNAs as biomarkers of ALS. Frontiers in Neurology, 10 (186). pp. 1-9. ISSN 1664-2295

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Abstract

Amyotrophic lateral sclerosis (ALS; MND, motor neuron disease) is a debilitating neurodegenerative disease affecting 4.5 per 100,000 people per year around the world. There is currently no cure for this disease, and its causes are relatively unknown. Diagnosis is based on a battery of clinical tests up to a year after symptom onset, with no robust markers of diagnosis or disease progression currently identified. A major thrust of current research is to identify potential non-invasive markers (“biomarkers”) in body fluids such as blood and/or cerebrospinal fluid (CSF) to use for diagnostic or prognostic purposes. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), are found at detectable and stable levels in blood and other bodily fluids. Specific ncRNAs can vary in levels between ALS patients and non-ALS controls without the disease. In this review, we will provide an overview of early findings, demonstrate the potential of this new class as biomarkers, and discuss future challenges and opportunities taking this forward to help patients with ALS.

Item Type: Article
Keywords: Motor neuron disease, Amyotrophic lateral sclerosis, Biomarker, microRNA, miRNA, non-coding RNA
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
School of Life Sciences > Neuroscience
Research Centres and Groups: Neurodegenerative Disease and Ageing Research Centre
Sussex Neuroscience
Subjects: Q Science > Q Science (General) > Q0179.9 Research
Depositing User: Majid Hafezparast
Date Deposited: 18 Feb 2019 09:56
Last Modified: 07 Mar 2019 15:39
URI: http://sro.sussex.ac.uk/id/eprint/81941

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