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Cognitive function, depressive symptoms and syphilis in HIV-positive and HIV-negative individuals

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posted on 2023-06-09, 16:45 authored by Davide De Francesco, Alan Winston, Jonathan Underwood, Fiona V Cresswell, Jane Anderson, Frank A Post, Ian Williams, Patrick W G Mallon, Memory Sachikonye, Daphne Babalis, Jaime Vera RojasJaime Vera Rojas, Emmanouil Bagkeris, Ana Milinkovic, Caroline A Sabin
We evaluated associations between history of syphilis infection and both cognitive function and depressive symptoms in people living with HIV (PLHIV) and comparable HIV-negative controls. Syphilis serological tests, cognitive function and depression were assessed in PLHIV and controls participating in the Pharmacokinetic and Clinical Observations in People Over Fifty study. Cognitive test scores were converted to demographically adjusted T-scores (mean?=?50, SD?=?10) and then averaged to obtain a global T-score. Severity of depressive symptoms was assessed via the Patient Health Questionnaire-9. Associations of syphilis with global T-scores and depression were assessed using median regression. The 623 PLHIV and 246 HIV-negative controls were predominantly male (89.3% and 66.5%) with median age (interquartile range [IQR]) of 57 (53–63) and 58 (53–63) years, respectively. PLHIV had lower global cognitive T-scores (median [IQR] 48.7 [45.1, 52.1] versus 50.5 [47.0, 53.9], p?

History

Publication status

  • Published

File Version

  • Accepted version

Journal

International Journal of STD and AIDS

ISSN

0956-4624

Publisher

SAGE Publications

Issue

5

Volume

30

Page range

440-446

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-02-05

First Open Access (FOA) Date

2019-02-06

First Compliant Deposit (FCD) Date

2019-02-05

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