A Bayesian account of the sensory-motor interactions underlying symptoms in Tourette syndrome

Rae, Charlotte L, Critchley, Hugo D and Seth, Anil K (2019) A Bayesian account of the sensory-motor interactions underlying symptoms in Tourette syndrome. Frontiers in Psychiatry, 10 (29). pp. 1-15. ISSN 1664-0640

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Abstract

Tourette syndrome is a hyperkinetic movement disorder. Characteristic features include tics, recurrent movements that are experienced as compulsive and “unwilled”; uncomfortable premonitory sensations that resolve through tic release; and often, the ability to suppress tics temporarily. We demonstrate how these symptoms and features can be understood in terms of aberrant predictive (Bayesian) processing in hierarchical neural systems, explaining specifically: why tics arise, their “unvoluntary” nature, how premonitory sensations emerge, and why tic suppression works—sometimes. In our model, premonitory sensations and tics are generated through over-precise priors for sensation and action within somatomotor regions of the striatum. Abnormally high precision of priors arises through the dysfunctional synaptic integration of cortical inputs. These priors for sensation and action are projected into primary sensory and motor areas, triggering premonitory sensations and tics, which in turn elicit prediction errors for unexpected feelings and movements. We propose experimental paradigms to validate this Bayesian account of tics. Our model integrates behavioural, neuroimaging, and computational approaches to provide mechanistic insight into the pathophysiological basis of Tourette syndrome.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
School of Engineering and Informatics > Informatics
Research Centres and Groups: Sackler Centre for Consciousness Science
Sussex Neuroscience
Depositing User: Alexei Fisk
Date Deposited: 31 Jan 2019 10:45
Last Modified: 01 Jul 2019 19:31
URI: http://sro.sussex.ac.uk/id/eprint/81572

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