Are SMC complexes loop extruding factors? Linking theory with fact

Baxter, Jonathan, Oliver, Antony W and Schalbetter, Stephanie A (2019) Are SMC complexes loop extruding factors? Linking theory with fact. BioEssays, 41 (1). 1800182 1-10. ISSN 1521-1878

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The extreme length of chromosomal DNA requires organizing mechanisms to both promote functional genetic interactions and ensure faithful chromosome segregation when cells divide. Microscopy and genome‐wide contact frequency analyses indicate that intra‐chromosomal looping of DNA is a primary pathway of chromosomal organization during all stages of the cell cycle. DNA loop extrusion has emerged as a unifying model for how chromosome loops are formed in cis in different genomic contexts and cell cycle stages. The highly conserved family of SMC complexes have been found to be required for DNA cis‐looping and have been suggested to be the enzymatic core of loop extruding machines. Here, the current body of evidence available for the in vivo and in vitro action of SMC complexes is discussed and compared to the predictions made by the loop extrusion model. How SMC complexes may differentially act on chromatin to generate DNA loops and how they could work to generate the dynamic and functionally appropriate organization of DNA in cells is explored.

Item Type: Article
Keywords: SMC complexes chromosome structure chromosome segregation
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Research Centres and Groups: Genome Damage and Stability Centre
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Depositing User: Jon Baxter
Date Deposited: 22 Jan 2019 10:18
Last Modified: 18 Feb 2022 16:26

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Project NameSussex Project NumberFunderFunder Ref
Investigating the interplay between SMC complexes and Topoisomerase IIG2520BBSRCBB/S001425/1
How do Smc5/6 interactions with DNA coordinate replication and recombination?G2119MRC-MEDICAL RESEARCH COUNCILMR/P018955/1