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Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?

journal contribution
posted on 2023-06-07, 13:50 authored by G. R. Davies, A. Ramani, C. M. Dalton, D. J. Tozer, C. A. Wheeler-Kingshott, G. J. Barker, A. J. Thompson, D. H. Miller, P. S. Tofts
We report on a new quantitative magnetization transfer (MT) technique that allows for the in vivo estimation of the macromolecular proton fraction (f) and the bound pool T2 relaxation time (T2b), whilst permitting whole brain coverage. In this pilot study, five subjects with multiple sclerosis (MS) and five healthy controls were studied. Both f and T2b were significantly different between MS lesions and normal control white matter (WM). Relationships between f and T1 relaxation time [Spearmans rank correlation coefficient (r(s)) = -0.97, P < 0.001] and f and the magnetization transfer ratio (MTR; r(s) = 0.80, P < 0.001) were observed. Compared with MTR, f and T2b have the potential advantage of relative independence from MT acquisition protocol while offering more pathologically specific information. In particular, f may provide a more direct indication of myelin content in WM.

History

Publication status

  • Published

Journal

Multiple Sclerosis

ISSN

1352-4585

Publisher

SAGE Publications

Issue

3

Volume

9

Page range

246-249

Department affiliated with

  • BSMS Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2007-02-28