Revised_Assessing the Severity of T2DM Using Clinical Data Based Measures a Systematic Review_DME_Nov2018_Clean_version_Final.pdf (548.73 kB)
Assessing the severity of Type 2 diabetes using clinical data based measures: a systematic review
journal contribution
posted on 2023-06-09, 16:31 authored by S S Zghebi, M Panagioti, M K Rutter, D M Ashcroft, Harm van MarwijkHarm van Marwijk, C Salisbury, C A Chew-Graham, I Buchan, N Qureshi, N Peek, C Mallen, M Mamas, E KontopantelisAims To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data-based diabetes-specific severity measures in adults with Type 2 diabetes were included. We excluded studies conducted solely in participants with other types of diabetes. After independent screening, the characteristics of the eligible measures including design and severity domains, the clinical utility of developed measures, and the relationship between severity levels and health-related outcomes were assessed. Results We identified 6798 studies, of which 17 studies reporting 18 different severity measures (32 314 participants in 17 countries) were included: a diabetes severity index (eight studies, 44%); severity categories (seven studies, 39%); complication count (two studies, 11%); and a severity checklist (one study, 6%). Nearly 89% of the measures included diabetes-related complications and/or glycaemic control indicators. Two of the severity measures were validated in a separate study population. More severe diabetes was associated with increased healthcare costs, poorer cognitive function and significantly greater risks of hospitalization and mortality. The identified measures differed greatly in terms of the included domains. One study reported on the use of a severity measure prospectively. Conclusions Health records are suitable for assessment of diabetes severity; however, the clinical uptake of existing measures is limited. The need to advance this research area is fundamental as higher levels of diabetes severity are associated with greater risks of adverse outcomes. Diabetes severity assessment could help identify people requiring targeted and intensive therapies and provide a major benchmark for efficient healthcare services.
History
Publication status
- Published
File Version
- Accepted version
Journal
Diabetic MedicineISSN
0742-3071Publisher
WileyExternal DOI
Issue
6Volume
36Page range
688-701Department affiliated with
- Primary Care and Public Health Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-01-15First Open Access (FOA) Date
2020-01-22First Compliant Deposit (FCD) Date
2019-01-15Usage metrics
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