exosome in CAD-revised (2) (1).pdf (368.89 kB)
The clinical impact of exosomes in cardiovascular disorders: from basic science to clinical application
journal contribution
posted on 2023-06-09, 16:17 authored by Farzaneh Ghafarian, Mehran Pashirzad, Majid Khazaei, Majid Rezayi, Seyed Mahdi Hassanian, Gordon FernsGordon Ferns, Amir AvanCardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of valid biomarker that accurately predict the risk of developing cardiovascular disease, and novel therapeutic approaches for its treatment. Exosomes are very small extracellular vesicles containing protein, lipid, transcription factors, mRNAs, non-coding RNA and nucleic acid contents, that are important players in intercellular communication, and that act via long-range signals or cell-to-cell contact. The discovery of exosomes provides potential strategies for the diagnosis and treatment of cardiovascular disease. In the current review, we have explored the potential impact of exosomes on cardiovascular physiology, and their therapeutic potential in cardiovascular disorders with a emphasize on the existing preclinical studies.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Cellular PhysiologyISSN
0021-9541Publisher
WileyExternal DOI
Issue
8Volume
234Page range
12226-12236Department affiliated with
- BSMS Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-12-19First Open Access (FOA) Date
2019-12-10First Compliant Deposit (FCD) Date
2018-12-18Usage metrics
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