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Statin in GI (FINAL 97.09.04) - Copy.pdf (1.04 MB)

The impact of statin therapy on the survival of patients with gastrointestinal cancer

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posted on 2023-06-09, 16:17 authored by Meysam Gachpazan, Hoda Kashani, Majid Khazaei, Seyed Mahdi Hassanian, Majid Rezayi, Fereshteh Asgharzadeh Yazdi, Majid Ghayour-Mobarhan, Gordon FernsGordon Ferns, Amir Avan
Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that may play an important role in the evolution of cancers, due to their effects on cancer cell metabolism. Statins effect several potential pathways, including: cell proliferation, angiogenesis, apoptosis and metastasis. The number of trials assessing the putative clinical benefits of statins in cancer is increasing. Currently, there are several trials listed on the global trial identifier website clinicaltrials.gov. Given the compelling evidence from these trials in a variety of clinical settings, there have been calls for a clinical trial of statins in the adjuvant gastrointestinal cancer setting. However, randomized controlled trials on specific cancer types in relation to statin use, as well as studies on populations without a clinical indication for using statins, have elucidated some potential underlying biological mechanisms, and the investigation of different statins is probably warranted. It would be useful for these trials to incorporate the assessment of tumour biomarkers predictive of statin response in their design. This review summarizes the recent preclinical and clinical studies that assess the application of statins in the treatment of gastrointestinal cancers with particular emphasize on their association with cancer risk.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Drug Targets

ISSN

1389-4501

Publisher

Bentham Science Publisher

Issue

1

Volume

20

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-12-19

First Open Access (FOA) Date

2020-05-10

First Compliant Deposit (FCD) Date

2018-12-18

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