Independent association between cardio-ankle vascular index and sarcopenia in older U.K. adults

Kirkham, Francis A, Bunting, Eva, Fantin, Francesco, Zamboni, Mauro and Rajkumar, Chakravarthi (2018) Independent association between cardio-ankle vascular index and sarcopenia in older U.K. adults. Journal of the American Geriatrics Society. ISSN 0002-8614

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OBJECTIVES: To investigate the correlation between sarcopenia and arterial stiffness in Caucasians, centering on the relationship between skeletal mass index (SMI) and the cardio-ankle vascular index (CAVI) to assess the use of CAVI in predicting sarcopenia.


PARTICIPANTS: UK adults aged 45 years and over (N = 366, n = 177 male, n = 189 female).

MEASUREMENTS: Bioimpedance analysis was used to derive SMI. CAVI score was calculated using a vascular screening system. Handgrip strength was measured using a standard dynamometer.

RESULTS: Average CAVI was significantly correlated with SMI (correlation coefficient (r) = −0.285, p < .001), with higher correlation in women (r = −0.416, p < .001) than men (r = −0.214, p = .01). CAVI had the highest correlation with SMI from appendicular muscle (fat-free mass in men, r = −0.253, p = .002; predicted muscle mass in women, r = −0.436, p < .001). There was a significant difference in average CAVI between groups, with participants who were not sarcopenic having lower CAVI (8.98) than those who were sarcopenic (9.80) (p < .001, t-test). Linear regression was performed using SMI as the dependent variable. After adjustment for age, average CAVI was a significant predictor of SMI in women (beta = −0.332, p < .001) but not men.

Item Type: Article
Keywords: sarcopenia, cardiovascular disease, arterial stiffness, skeletal mass index, cardio-ankle vascular index
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Marie Shelton
Date Deposited: 29 Nov 2018 11:07
Last Modified: 02 Jul 2019 13:47

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