Anemia is associated with cognitive impairment in adolescent girls: a cross-sectional survey

Bahrami, Afsane, Khorasanchi, Zahra, Tayefi, Maryam, Avan, Amir, Seifi, Najmeh, Sany, Seyedeh Belin Tavakoly, Ferns, Gordon A, Bahrami-Taghanaki, Hamidreza and Ghayour-Mobarhan, Majid (2019) Anemia is associated with cognitive impairment in adolescent girls: a cross-sectional survey. Applied Neuropsychology: Child. ISSN 2162-2965

[img] PDF - Accepted Version
Download (699kB)

Abstract

Anemia is associated with impairment in oxygen transport, affecting an individual’s physical and mental wellbeing, and work performance. The aim of this study was to examine the prevalence of anemia and its possible association with serum antibody titers to Hsp27 (as an indicator of cellular stress), cognitive function, measures of emotion, sleep patterns in adolescent girls. A total of 940 adolescent girls were assessed to evaluate neuropsychological function with validated questionnaires. A complete blood count was determined as part of the assessment of hematological parameters. Serum anti-Hsp27 was measured for each subject. Among the total of 940 participants, 99 girls (10.5%) were anemic [hemoglobin <12(g/dl)]. Serum anti-HSP27 was significantly higher in anemic compared to healthy girls (p<0.05). There was no significant differences in depression, aggression, insomnia, daytime sleepiness and sleep apnea score between two groups. However, the total cognitive abilities score was significantly lower in the anemic girls (76.8±2.1 versus 85.7±2.5, p = 0.002). Logistic regression analysis showed that anemic girls were 1.73 times more likely than non-anemic girls to have cognitive impairment (95% confidence interval [CI] = 1.07-2.78; P = 0.025). Anemia was associated with elevated levels of anti-HSP27 and supports the hypothesis that cellular stress may be associated with anemia. Anemia was adversely associated with an assessment of cognitive abilities and was an independent risk factor for cognitive impairment in this group

Item Type: Article
Keywords: Heat shock protein; cognitive ability; depression; sleep disorder
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 15 Nov 2018 16:38
Last Modified: 20 Jan 2020 02:00
URI: http://sro.sussex.ac.uk/id/eprint/80235

View download statistics for this item

📧 Request an update