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Anemia is associated with cognitive impairment in adolescent girls: a cross-sectional survey

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posted on 2023-06-09, 15:54 authored by Afsane Bahrami, Zahra Khorasanchi, Maryam Tayefi, Amir Avan, Najmeh Seifi, Seyedeh Belin Tavakoly Sany, Gordon FernsGordon Ferns, Hamidreza Bahrami-Taghanaki, Majid Ghayour-Mobarhan
Anemia is associated with impairment in oxygen transport, affecting an individual’s physical and mental wellbeing, and work performance. The aim of this study was to examine the prevalence of anemia and its possible association with serum antibody titers to Hsp27 (as an indicator of cellular stress), cognitive function, measures of emotion, sleep patterns in adolescent girls. A total of 940 adolescent girls were assessed to evaluate neuropsychological function with validated questionnaires. A complete blood count was determined as part of the assessment of hematological parameters. Serum anti-Hsp27 was measured for each subject. Among the total of 940 participants, 99 girls (10.5%) were anemic [hemoglobin <12(g/dl)]. Serum anti-HSP27 was significantly higher in anemic compared to healthy girls (p<0.05). There was no significant differences in depression, aggression, insomnia, daytime sleepiness and sleep apnea score between two groups. However, the total cognitive abilities score was significantly lower in the anemic girls (76.8±2.1 versus 85.7±2.5, p = 0.002). Logistic regression analysis showed that anemic girls were 1.73 times more likely than non-anemic girls to have cognitive impairment (95% confidence interval [CI] = 1.07-2.78; P = 0.025). Anemia was associated with elevated levels of anti-HSP27 and supports the hypothesis that cellular stress may be associated with anemia. Anemia was adversely associated with an assessment of cognitive abilities and was an independent risk factor for cognitive impairment in this group

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Applied Neuropsychology: Child

ISSN

2162-2965

Publisher

Taylor & Francis

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-11-15

First Open Access (FOA) Date

2020-01-20

First Compliant Deposit (FCD) Date

2018-11-13

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