EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation

Binabaj, Maryam M, Asgharzadeh, Fereshteh, Avan, Amir, Rahmani, Farzad, Soleimani, Atena, Parizadeh, Mohammad R, Ferns, Gordon A, Ryzhikov, Mikhail, Khazaei, Majid and Hassanian, Seyed M (2019) EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation. Journal of Cellular Physiology, 234 (7). pp. 11654-11661. ISSN 0021-9541

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Abstract

EW‐7197 is a transforming growth factor‐β type I receptor kinase inhibitor with potential anti‐inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW‐7197 in a murine model of ulcerative colitis. EW‐7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW‐7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW‐7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing submucosal edema and inflammatory cell infiltration, downregulating proinflammatory and pro‐fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW‐7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Elizabeth Renvoize
Date Deposited: 15 Nov 2018 16:41
Last Modified: 27 Nov 2019 02:00
URI: http://sro.sussex.ac.uk/id/eprint/80234

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