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EW-7197 prevents ulcerative colitis-associated fibrosis and inflammation

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posted on 2023-06-09, 15:54 authored by Maryam M Binabaj, Fereshteh Asgharzadeh, Amir Avan, Farzad Rahmani, Atena Soleimani, Mohammad R Parizadeh, Gordon FernsGordon Ferns, Mikhail Ryzhikov, Majid Khazaei, Seyed M Hassanian
EW-7197 is a transforming growth factor-ß type I receptor kinase inhibitor with potential anti-inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW-7197 in a murine model of ulcerative colitis. EW-7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW-7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW-7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing submucosal edema and inflammatory cell infiltration, downregulating proinflammatory and pro-fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW-7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Cellular Physiology

ISSN

0021-9541

Publisher

Wiley

Issue

7

Volume

234

Page range

11654-11661

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-11-15

First Open Access (FOA) Date

2019-11-27

First Compliant Deposit (FCD) Date

2018-11-13

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