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Adjunctive rifampicin to reduce early mortality - 2018.pdf (4.55 MB)

Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT

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posted on 2023-06-09, 15:46 authored by Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Pedro Saramago Goncalves, Marta Soares, Jennifer Bostock, Emmanuel Nsutebu, Robert Tilley, Richard Cunningham, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Timothy Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin LlewelynMartin Llewelyn, Jonathan D Edgeworth, A Sarah Walker
Background Staphylococcus aureus bacteraemia is a common and frequently fatal infection. Adjunctive rifampicin may enhance early S. aureus killing, sterilise infected foci and blood faster, and thereby reduce the risk of dissemination, metastatic infection and death. Objectives To determine whether or not adjunctive rifampicin reduces bacteriological (microbiologically confirmed) failure/recurrence or death through 12 weeks from randomisation. Secondary objectives included evaluating the impact of rifampicin on all-cause mortality, clinically defined failure/recurrence or death, toxicity, resistance emergence, and duration of bacteraemia; and assessing the cost-effectiveness of rifampicin. Design Parallel-group, randomised (1?:?1), blinded, placebo-controlled multicentre trial. Setting UK NHS trust hospitals. Participants Adult inpatients (=?18 years) with meticillin-resistant or susceptible S. aureus grown from one or more blood cultures, who had received

History

Publication status

  • Published

File Version

  • Published version

Journal

Health Technology Assessment

ISSN

1366-5278

Publisher

NIHR Journals Library

Issue

59

Volume

22

Page range

1-148

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-11-07

First Open Access (FOA) Date

2018-11-07

First Compliant Deposit (FCD) Date

2018-11-07

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