Computerized exposure therapy for Spider Phobia: Effects of cardiac timing and interoceptive ability on subjective and behavioral outcomes

Watson, David R, Garfinkel, Sarah N, Gould van Praag, Cassandra, Willmott, Daniel, Wong, Katherine, Meeten, Frances and Critchley, Hugo D (2019) Computerized exposure therapy for Spider Phobia: Effects of cardiac timing and interoceptive ability on subjective and behavioral outcomes. Psychosomatic Medicine, 81 (1). pp. 90-99. ISSN 0033-3174

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Abstract

Objective: Spider phobia is a common form of anxiety disorder for which exposure therapy is an effective first-line treatment. Motivated by the observed modulation of threat processing by afferent cardiac signals; we tested the hypothesis that interoceptive information concerning cardiovascular arousal can influence the outcomes of computerised exposure therapy for spider phobia.

Method: Fifty-three normal healthy participants with high spider phobia scores underwent one of three modified computerised exposure protocols, defined by the timing of exposure to brief spider stimuli within the cardiac cycle: Systole (during afferent baroreceptor firing); Diastole (during baroreceptor-quiescent interbeat interval); Random (non-contingent on cardiac cycle). Outcomes were judged on phobic and anxiety measures and physiological data (skin conductance). Subjects were also rated on interoceptive accuracy.

Results: Mancova analysis showed that timing group affected the outcome measures (F(10,80)=2.405, p=0.015) and there was a group interaction with interoception ability (F(15,110)=1.808, p=0.045). Subjective symptom reduction (SPQ) was greatest in the Systolic group relative to the other two groups (Diastolic (t=3.115, ptukey=0.009); Random (t=2.438, ptukey=0.048), with greatest reductions in those participants with lower interoceptive accuracy. Behavioural aversion (BAT) reduced more in cardiac-contingent groups than the non-contingent (Random) group (Diastolic (t=3.295, ptukey=0.005); Systolic (t=2.602, ptukey=0.032). Physiological (SCR) responses remained strongest for spider stimuli presented at cardiac systole.

Conclusion: Interoceptive information influences exposure benefit. The reduction in the subjective expression of fear/phobia is facilitated by ‘bottom-up’ afferent signals; while improvement in the behavioural expression is further dependent on ‘top-down’ representation of
Interoceptive effects in spider phobia treatment
self-related physiology (heart rhythm). Individual interoceptive differences moderate these effects, suggesting means to personalise therapy.

Item Type: Article
Keywords: Exposure Therapy, Phobia, Interoception, Cardiac Timing
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Neuroscience
Research Centres and Groups: Sackler Centre for Consciousness Science
Sussex Neuroscience
Depositing User: Alexei Fisk
Date Deposited: 18 Oct 2018 15:08
Last Modified: 11 Jan 2019 17:03
URI: http://sro.sussex.ac.uk/id/eprint/79566

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Project NameSussex Project NumberFunderFunder Ref
Cardiac control of fear in brainG1120EUROPEAN UNION324150 CCFIB