Evidence of cerebellar involvement in the onset of a manic state

Lupo, Michela, Olivito, Giusy, Siciliano, Libera, Masciullo, Marcella, Molinari, Marco, Cercignani, Mara, Bozzali, Marco and Leggio, Maria (2018) Evidence of cerebellar involvement in the onset of a manic state. Frontiers in Neurology, 9 (774). pp. 1-6. ISSN 1664-2295

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)


We described the cerebello-cerebral functional connectivity in a subject who developed a manic state after a cerebellar lesion. Whole brain investigation, performed by means of an advanced MRI examination, evidenced an isolated lesion involving the left lobules VI, VIIa (crus I), and IX and the posterior area of the vermis. The cerebello-cerebral functional connectivity analysis detected a pattern of altered connectivity in specific areas of the prefrontal-striatal-thalamic circuits that are typically altered in bipolar subjects during the manic state. Specifically, a pattern of hypo-connectivity was found between the cerebellum and cerebral regions known to be implicated in emotion modulation and social interaction. Conversely, a pattern of hyper-connectivity was found between the cerebellum and posterior cerebral cortical regions that are involved in sensorimotor functions. The present study represents the first evidence that dysregulation of cerebral networks consequent to a cerebellar lesion is at the root of bipolar disorder, at least the manic state, and provides a new framework for interpreting cerebellar modulation in the regulation of mood in specific psychiatric conditions.

Item Type: Article
Keywords: mania, cerebellum, MRI, bipolar disorder, mood
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Patricia Butler
Date Deposited: 02 Oct 2018 12:59
Last Modified: 01 Jul 2019 15:30
URI: http://sro.sussex.ac.uk/id/eprint/79145

View download statistics for this item

📧 Request an update