D'Amelio, Marcello, Serra, Laura and Bozzali, Marco (2018) Ventral tegmental area in prodromal Alzheimer's disease: bridging the gap between mice and humans. Journal of Alzheimer's Disease, 63 (1). pp. 181-183. ISSN 1875-8908

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Abstract

Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.

Item Type:	Article
Keywords:	Alzheimer’s disease, dopamine, hippocampus, memory, midbrain, ventral tegmental area
Schools and Departments:	Brighton and Sussex Medical School > Neuroscience
Subjects:	R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User:	Patricia Butler
Date Deposited:	09 May 2019 13:10
Last Modified:	06 Dec 2019 13:46
URI:	http://sro.sussex.ac.uk/id/eprint/79133

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