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Ventral tegmental area in prodromal Alzheimer's disease: bridging the gap between mice and humans

journal contribution
posted on 2023-06-09, 15:17 authored by Marcello D'Amelio, Laura Serra, Marco Bozzali
Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.

History

Publication status

  • Published

Journal

Journal of Alzheimer's Disease

ISSN

1875-8908

Publisher

IOS Press

Issue

1

Volume

63

Page range

181-183

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2019-05-09

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