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Ventral tegmental area in prodromal Alzheimer's disease: bridging the gap between mice and humans
journal contribution
posted on 2023-06-09, 15:17 authored by Marcello D'Amelio, Laura Serra, Marco BozzaliAlzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.
History
Publication status
- Published
Journal
Journal of Alzheimer's DiseaseISSN
1875-8908Publisher
IOS PressExternal DOI
Issue
1Volume
63Page range
181-183Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2019-05-09Usage metrics
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