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Serra and Gelfo et al 18-0609 REV2.pdf (380.93 kB)

Rethinking the reserve with a translational approach: novel ideas on the construct and the interventions

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posted on 2023-06-09, 15:17 authored by Laura Serra, Francesca Gelfo, Laura Petrosini, Carlotta Di Domenico, Marco Bozzali, Carlo Caltagirone
The concept of brain, cognitive, and neural reserves has been introduced to account for the apparent discrepancies between neurological damage and clinical manifestations. However, these ideas are yet theoretical suggestions that are not completely assimilated in the clinical routine. The mechanisms of the reserves have been extensively studied in neurodegenerative pathologies, in particular in Alzheimer's disease. Both human and animal studies addressed this topic by following two parallel pathways. The specific aim of the present review is to attempt to combine the suggestions derived from the two different research fields to deepen the knowledge about reserves. In fact, the achievement of a comprehensive theoretical framework on reserve mechanisms is an essential step to propose well-timed interventions tailored to the clinical characteristics of patients. The present review highlights the importance of addressing three main aspects: the definition of reserve proxy measures, the interaction between reserve level and therapeutic interventions, and the specific time-window of reserve efficacy.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Alzheimer's Disease

Publisher

IOS Press

Issue

4

Volume

65

Page range

1065-1078

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-11-01

First Open Access (FOA) Date

2018-11-01

First Compliant Deposit (FCD) Date

2018-11-01

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