Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents

Afolabi, Fatai, Souissi, Wided, Rivière, Guillaume, Lemaitre, Clement, Roe, Mark, Crickmore, Neil and Viseux, Eddy (2018) Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents. Dalton Transactions, 47 (43). pp. 15338-15343. ISSN 1477-9226

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Abstract

A new series of cationic gold(I) pyrazole complexes were prepared in excellent yields as their perchlorate salts. Results of cell viability assays show that these novel complexes have good cytotoxic properties against the human HepG2 cancer cell line. These complexes showed promising anti-cancer activities and to our knowledge, pyrazoles have never been tested against this cell line. The regioselectivity of the complexation is also discussed in regards to the substitution pattern of the pyrazoles.

Item Type: Article
Keywords: cancer, gold, liver cancer, HepG2, pyrazole, complexes, cytotoxic, heteroleptic
Schools and Departments: School of Life Sciences > Biochemistry
School of Life Sciences > Chemistry
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD0146 Inorganic chemistry
Q Science > QD Chemistry > QD0241 Organic chemistry
Q Science > QD Chemistry > QD0241 Organic chemistry > QD0411 Organometallic chemistry and compounds
R Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens > RC0261 Cancer and other malignant neoplasms
R Medicine > RM Therapeutics. Pharmacology > RM0300 Drugs and their actions
R Medicine > RS Pharmacy and materia medica > RS0153 Materia medica > RS0400 Pharmaceutical chemistry > RS0420 Drug design
Depositing User: Eddy Viseux
Date Deposited: 27 Sep 2018 10:26
Last Modified: 06 Dec 2018 14:48
URI: http://sro.sussex.ac.uk/id/eprint/79050

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