Survival following Staphylococcus aureus bloodstream infection; a prospective multinational cohort study assessing the impact of place of care

Nambiar, Kate, Seifert, Harald, Riert, Siegbert, Kern, Winfried V, Scarborough, Matt, Gordon, N Claire, Kim, Hong Bin, Song, Kyoung-Ho, Tilley, Robert, Gott, Hannah, Liao, Chun Hsing, Edgeworth, Jonathan, Nsutebu, Emmanuel, López-Cortés, Luis Eduardo, Morata, Laura, Walker, A Sarah, Thwaites, Guy, Llewelyn, Martin J, Kaasch, Achim J, International Staphylococcus aureus collaboration study group, and ESCMID Study Group for Bloodstream Infections and Sepsis, (2018) Survival following Staphylococcus aureus bloodstream infection; a prospective multinational cohort study assessing the impact of place of care. Journal of Infection, 77 (6). pp. 516-525. ISSN 0163-4453

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Abstract

Background
Staphylococcus aureus bloodstream infection (SAB) is a common, life-threatening infection with a high mortality. Survival can be improved by implementing quality of care bundles in hospitals. We previously observed marked differences in mortality between hospitals and now assessed whether mortality could serve as a valid and easy to implement quality of care outcome measure.

Methods
We conducted a prospective observational study between January 2013 and April 2015 on consecutive, adult patients with SAB from 11 tertiary care centers in Germany, South Korea, Spain, Taiwan, and the United Kingdom. Factors associated with mortality at 90 days were analyzed by Cox proportional hazards regression and flexible parametric models.

Results
1,851 patients with a median age of 66 years (64% male) were analyzed. Crude 90-day mortality differed significantly between hospitals (range 23% to 39%). Significant variation between centers was observed for methicillin-resistant S. aureus, community-acquisition, infective foci, as well as measures of comorbidities, and severity of disease. In multivariable analysis, factors independently associated with mortality at 90 days were age, nosocomial acquisition, unknown infective focus, pneumonia, Charlson comorbidity index, SOFA score, and study center. The risk of death varied over time differently for each infective focus. Crude mortality differed markedly from adjusted mortality.

Discussion
We observed significant differences in adjusted mortality between hospitals, suggesting differences in quality of care. However, mortality is strongly influenced by patient mix and thus, crude mortality is not a suitable quality indicator.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User: Sandy Gray
Date Deposited: 11 Sep 2018 13:56
Last Modified: 02 Jul 2019 13:21
URI: http://sro.sussex.ac.uk/id/eprint/78638

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