Intron size and exon evolution in Drosophila

Marais, Gabriel, Nouvellet, Pierre, Keightley, Peter D and Charlesworth, Brian (2005) Intron size and exon evolution in Drosophila. Genetics, 170 (1). pp. 481-485. ISSN 0016-6731

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We have found a negative correlation between evolutionary rate at the protein level (as measured by d(N)) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Pierre Nouvellet
Date Deposited: 17 Aug 2018 15:34
Last Modified: 02 Jul 2019 14:49

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